File:SilentSynapseFig2.jpg
Summary
Figure 2: Alternative models for silent synapses. The most widely accepted model to explain NMDA-only synaptic transmission is that these receptors are absent from the postsynaptic density (or non-functional) at a proportion of synapses (A). An alternative hypothesis to explain NMDA-only transmission is that glutamate is released in such a manner that it reaches too low a concentration to activate AMPA receptors (B). The higher affinity of NMDA receptors for glutamate would explain why these receptors are able to mediate transmission. A third hypothesis holds that, because of their high sensitivity, NMDA receptors are able to detect spillover of glutamate from neighboring synapses (C).
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| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 19:58, 20 December 2010 | | 505 × 466 (34 KB) | Dimitri Kullmann (Talk | contribs) | Figure 2: Alternative models for silent synapses. The most widely accepted model to explain NMDA-only synaptic transmission is that these receptors are absent from the postsynaptic density (or non-functional) at a proportion of synapses (A). An alternativ |
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